A major Alzheimer’s risk gene may shrink brain cells years before symptoms

Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life. Reducing Nell2 in adult mice reversed the abnormal changes, raising hopes for a new way to intervene before Alzheimer’s progresses.

from All Top News -- ScienceDaily https://ift.tt/w9xUOnY

This shark can live 400 years. Its eyes barely seem to age

Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted for seeing blue light in the dim Arctic depths. DNA repair mechanisms may help keep their eyes functioning across centuries. The discovery could eventually offer new clues for protecting human vision as we age.

from All Top News -- ScienceDaily https://ift.tt/dqUrykT

Archaeologists discover mysterious 400-year-old Indigenous pot in Florida

A tiny, fully intact Indigenous pot buried for roughly 400 years has left archaeologists wondering why such a usable object was deliberately abandoned. Found at a historic Potano-Timucua village in Florida, the mysterious vessel is helping reveal a complex world of Native traditions, Spanish influence, trade, and migration.

from All Top News -- ScienceDaily https://ift.tt/8ZHlwOX

Ozempic does something unexpected to the brain’s hunger neurons

Ozempic may work in the brain in almost the opposite way scientists expected, activating hunger-linked neurons that appear essential for sustaining fat loss. The surprising discovery in mice could reveal new targets for developing even more effective obesity drugs.

from All Top News -- ScienceDaily https://ift.tt/xhc7rmG

Scientists say the human family tree may need a major rewrite

The human family tree may be due for a major rewrite. Researchers argue that Australopithecus and Paranthropus should be folded into the genus Homo because new fossils have blurred many of the traits once used to separate them. The proposed shake-up could provide a simpler, more accurate picture of our surprisingly complicated evolutionary past.

from All Top News -- ScienceDaily https://ift.tt/tLd0ATG

Researchers reveal deeper workings of brain’s information hub

The brain has a remarkably flexible system for handling uncertainty and changing situations. Researchers found that the frontoparietal cortex constantly shifts how it communicates with other brain regions depending on what information is needed to make a decision. Rather than simply becoming more active when things get difficult, this network appears to reorganize itself in real time.

from All Top News -- ScienceDaily https://ift.tt/6KSs0ZF

Mysterious waves sweeping across your brain may help turn sensory chaos into what you see

Traveling electrical waves sweeping across the brain may help determine what we notice, predict what comes next, and construct our internal picture of the world. Researchers now argue that these waves aren't just background activity—they could be a core computational engine behind perception and memory.

from All Top News -- ScienceDaily https://ift.tt/5Y9GXaQ

A therapy that “rewrites” childhood memories can ease fear of failure

Childhood criticism can leave people carrying a fear of failure long into adulthood, but new research suggests those emotional patterns may be surprisingly flexible. Young adults who revisited painful memories through imagery-based therapy showed lasting reductions in fear, guilt, sadness, and stress.

from All Top News -- ScienceDaily https://ift.tt/dcBRVnp

Scientists uncover the hidden nerve network fueling breast cancer

Researchers have uncovered a surprising way triple-negative breast cancer may turn the body against itself. Tumors appear to recruit macrophages—immune cells normally involved in healing and fighting infection—and use them to release a protein called BDNF that draws nerves into the tumor. Those nerves may then help the cancer grow, resist treatment, and potentially spread.

from All Top News -- ScienceDaily https://ift.tt/MVlUOgR

A little-known protein may be fueling Alzheimer’s — and scientists found a way to block it

An experimental Alzheimer’s compound prevented damaging protein clumps from forming in the brains of mice, helping nerve cells survive longer and reducing amyloid buildup. The treatment also appeared to improve heart health and slow some signs of aging, raising hopes for an entirely new way to combat dementia.

from All Top News -- ScienceDaily https://ift.tt/79Mlw5u

COVID-19 awakens dormant viruses — and one is linked to long COVID

COVID-19 can reactivate dormant viruses hiding in the body, including Epstein-Barr, cytomegalovirus, and several herpes viruses. One poorly understood viral family was strongly associated with long COVID and lasting disability, offering a potentially important clue to why some patients struggle to recover.

from All Top News -- ScienceDaily https://ift.tt/NJlA5w8

A 60-year-old theory about ants, bees and wasps may be wrong

Scientists have long thought an unusual genetic system helped ants, bees, and wasps evolve their extraordinary social colonies. A massive new analysis suggests that genetics alone can’t explain it—and the real secret may lie in other traits unique to these insects.

from All Top News -- ScienceDaily https://ift.tt/qp2Tz31

Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways

Scientists have uncovered why two seemingly opposite ways of targeting the same brain receptor can both promote weight loss. In mice, activating the GIP receptor in the brainstem reduced appetite, while blocking it in the hypothalamus removed a kind of “brake” on fullness signals. The discovery helps explain why very different obesity drugs can achieve similar results and suggests that carefully combining GIP-targeting treatments with GLP-1 drugs like those related to Wegovy and Ozempic could produce stronger effects.

from All Top News -- ScienceDaily https://ift.tt/Vu5vqNn